ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes
2007
Abstract
Electrospray ionization mass spectrometry allows a rapid characterization of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compds. and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metalation was readily obtained.
Details
Title
ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes
Author(s)
Casini, A ; Mastrobuoni, G ; Ang, WH ; Gabbiani, C ; Pieraccini, G ; Moneti, G ; Dyson, PJ ; Messori, L
Published in
CHEMMEDCHEM
Volume
2
Issue
5
Pages
631-635
Date
2007
Laboratories
LCOM
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2007-06-13