Biological properties of a CD4 immunoadhesin
Molecular fusions of CD4, the receptor for human immunodeficiency virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4, and certain properties of IgG, notably long plasma half-life and Fc receptor binding. Here we show that a CD4 immunoadhesin can mediate antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells, although, unlike natural anti-gp120 antibodies, it does not allow ADCC towards uninfected CD4-expressing cells that have bound soluble gp120 to the CD4 on their surface. In addition, CD4 immunoadhesin, like natural IgG molecules, is efficiently transferred across the placenta of a primate. These observations have implications for the therapeutic application of CD4 immunoadhesins, particularly in the area of perinatal transmission of HIV infection.
- URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1970124
Keywords: Acquired Immunodeficiency Syndrome/congenital/immunology ; Animals ; Antibodies ; Anti-Idiotypic/*immunology ; Antibody-Dependent Cell Cytotoxicity/immunology ; Antigens ; CD/*immunology ; CD4 Immunoadhesins ; CD4-Positive T-Lymphocytes/immunology/microbiology ; Female ; HIV/*immunology ; HIV Envelope Protein gp120/immunology ; Humans ; Immunity ; Maternally-Acquired ; Immunoglobulin G/*immunology ; Macaca mulatta ; Pregnancy ; Recombinant Proteins
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Record created on 2007-06-05, modified on 2016-08-08