The Myc trilogy: lord of RNA polymerases
Cancer cells have a raised cellular metabolism, including increased protein biosynthesis. Three new studies now show that the oncoprotein Myc, known to drive cell division, also enhances ribosomal RNA synthesis by RNA polymerase I in addition to controlling RNA polymerase II- and III-regulated gene transcription. This suggests that Myc promotes the generation of crucial components of a functional ribosome.
Thordur Oskarsson and Andreas Trumpp are at the Swiss Institute for Experimental Cancer Research (ISREC), 1066 Epalinges, Switzerland. firstname.lastname@example.org.
Record created on 2007-05-22, modified on 2016-08-08