The Myc trilogy: lord of RNA polymerases

Cancer cells have a raised cellular metabolism, including increased protein biosynthesis. Three new studies now show that the oncoprotein Myc, known to drive cell division, also enhances ribosomal RNA synthesis by RNA polymerase I in addition to controlling RNA polymerase II- and III-regulated gene transcription. This suggests that Myc promotes the generation of crucial components of a functional ribosome.


Published in:
Nature Cell Biology, 7, 3, 215-7
Year:
2005
Note:
Thordur Oskarsson and Andreas Trumpp are at the Swiss Institute for Experimental Cancer Research (ISREC), 1066 Epalinges, Switzerland. andreas.trumpp@isrec.ch.
Laboratories:




 Record created 2007-05-22, last modified 2018-03-17


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