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We present an application in multi-parametrized sub-domains based on a technique for the rapid and reliable prediction of linear-functional outputs of elliptic coercive partial differential equations with affine parameter dependence (reduced-basis methods). The main components are (i) rapidly convergent global reduced-basis approximations-Galerkin projection onto a space WN spanned by solutions of the governing equation at N selected points in parameter space (chosen by an adaptive procedure to minimize the estimated error and the effectivity; (ii) a posteriori error estimation-relaxations of the error-residual equation that provide inexpensive bounds for the error in the outputs of interest; and (iii) off-line/on-line computational procedures-methods which decouple the generation and projection stages of the approximation process. The operation count for the on-line stage-in which, given a new parameter value, we calculate the output of interest and associated error bound-depends only on N (typically very small) and the parametric complexity of the problem; the method is thus ideally suited for the repeated and rapid evaluations required in the context of parameter estimation, design, optimization, and real-time control. The application is based on a heat transfer problem in a parametrized geometry in view of haemodynamics applications and biomechanical devices optimization, such as the bypass configuration problem. [All rights reserved Elsevier]