000102505 001__ 102505
000102505 005__ 20180318102412.0
000102505 0247_ $$2doi$$a10.1002/dvdy.21000
000102505 02470 $$2DAR$$a10000
000102505 02470 $$2ISI$$a000243466400025
000102505 037__ $$aARTICLE
000102505 245__ $$aNotch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner
000102505 269__ $$a2007
000102505 260__ $$c2007
000102505 336__ $$aJournal Articles
000102505 500__ $$aISREC (Swiss Institute for Experimental Cancer Research), National Center of Competence in Research (NCCR) Molecular Oncology, Epalinges, Switzerland; 1058-8388 (Print);Journal Article
000102505 520__ $$aThe Notch signaling pathway is involved in diverse biological processes such as cell fate decisions or stem cell maintenance. In this study, we assessed the role of this pathway for melanocyte development and hair pigmentation using RBP-Jkappa, Notch1, and Notch2 conditional knockout mice. Disruption of the Notch pathway by inactivating RBP-Jkappa in the melanocyte lineage using Tyr::Cre mice led to a severe coat color dilution. Similarly, hair graying was observed when Notch1 and/or Notch2 receptors were ablated in melanocytes. This phenotype was proportional to the number of floxed Notch alleles, with the most pronounced effect seen in Tyr::Cre/ degrees ; Notch1(flox/flox); Notch2(flox/flox) mice. Deletion of Notch1 and/or Notch2 in melanoblasts did not induce a congenital defect. The number of Dct-expressing cells at embryonic stages was not affected, but melanocytes located within the hair matrix progressively disappeared during the first regeneration of the hair follicle. In contrast, non-follicular melanocytes and pigmentation in the dermis and in the choroid were not affected. We suggest that both Notch1 and Notch2 receptors contribute to the maintenance of melanoblasts and melanocyte stem cells, and are essential for proper hair pigmentation.
000102505 700__ $$aSchouwey, K.
000102505 700__ $$aDelmas, V.
000102505 700__ $$aLarue, L.
000102505 700__ $$aZimber-Strobl, U.
000102505 700__ $$aStrobl, L. J.
000102505 700__ $$0240231$$aRadtke, F.$$g172749
000102505 700__ $$0240256$$aBeermann, F.$$g169239
000102505 773__ $$j236$$k1$$q282-289$$tDev Dyn
000102505 909CO $$ooai:infoscience.tind.io:102505$$pSV$$particle
000102505 909C0 $$0252092$$pGR-BEERMANN$$xU11779
000102505 909C0 $$0252086$$pUPRAD$$xU11429
000102505 937__ $$aUPRAD-ARTICLE-2007-003
000102505 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000102505 980__ $$aARTICLE