000101242 001__ 101242
000101242 005__ 20181203020748.0
000101242 0247_ $$2doi$$a10.1097/00001756-199806010-00027
000101242 022__ $$a0959-4965
000101242 037__ $$aARTICLE
000101242 245__ $$aNeurturin protects dopaminergic neurons following medial forebrain bundle axotomy
000101242 260__ $$c1998
000101242 269__ $$a1998
000101242 336__ $$aJournal Articles
000101242 500__ $$aDivision of Surgical Research and Gene Therapy Center, CHUV, Lausanne, Switzerland.
000101242 520__ $$aTo determine whether neurturin (NTN), a recently identified homologue of glial cell line-derived neurotrophic factor (GDNF), is able to preserve tyrosine hydroxylase immunoreactivity (TH-IR) in a rat model of Parkinson's disease, polymer encapsulated cells genetically engineered to release NTN were implanted near the substantia nigra 1 week before a unilateral medial forebrain bundle axotomy. Animals were allowed to survive for 1 week post-axotomy. Upon sacrifice, animals that received a NTN capsule had a significantly higher percentage of TH-IR (lesioned side vs non-lesioned side) than animals that had received a capsule containing non-transfected parent cells. However, in contrast to GDNF, no reduction of turning was observed upon amphetamine rotation with NTN. Nevertheless, these results suggest that NTN might have a therapeutic value for the treatment of Parkinson's disease.
000101242 6531_ $$aAnalysis of Variance
000101242 6531_ $$aAnimals
000101242 6531_ $$aAxotomy
000101242 6531_ $$aCell Line
000101242 6531_ $$aCricetinae
000101242 6531_ $$aDopamine/ physiology
000101242 6531_ $$aFemale
000101242 6531_ $$aImmunohistochemistry
000101242 6531_ $$aNerve Growth Factors/ pharmacology
000101242 6531_ $$aNeurons/ drug effects
000101242 6531_ $$aNeuroprotective Agents/ pharmacology
000101242 6531_ $$aNeurturin
000101242 6531_ $$aProsencephalon/ drug effects/surgery
000101242 6531_ $$aRats
000101242 6531_ $$aRats
000101242 6531_ $$aWistar
000101242 6531_ $$aTyrosine 3-Monooxygenase/analysis
000101242 700__ $$aTseng, J. L.
000101242 700__ $$aBruhn, S. L.
000101242 700__ $$aZurn, A. D.
000101242 700__ $$g104359$$aAebischer, P.$$0240206
000101242 773__ $$j9$$tNeuroreport$$k8$$q1817-22
000101242 909C0 $$xU10457$$0252067$$pLEN
000101242 909CO $$pSV$$particle$$ooai:infoscience.tind.io:101242
000101242 937__ $$aLEN-ARTICLE-1998-009
000101242 970__ $$a82/LEN
000101242 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000101242 980__ $$aARTICLE