CF3-bearing aromatic and heterocyclic building blocks

A review. Fluorine remains an insiders' tip in the life sciences as it enables the fine-tuning of biol. properties. However, the synthesis of fluorine-substituted target compds. is not always trivial. Virtually any fluorine atom attached to an org. backbone has ultimately to be imported from inorg. sources. Crucial for the entire synthetic planning in medicinal and agricultural research is the decision on at what stage and how the halogen will be introduced. Std. tech. processes, in particular the displacement of chlorine using anhyd. hydrogen fluoride or potassium fluoride, can hardly be implemented rationally on the lab. scale. Universal methods that are applicable by both industrial and academic researchers thus have great appeal. If a trifluoromethyl-substituted arene or heterocycle is the target compd., two splendid options exist. The CF3 group can be delivered packagewise by coupling an appropriate substrate with in situ generated (trifluoromethyl)copper. Alternatively, one may start from a CF3-substituted arene or heterocycle as a core and complete it with the missing parts of the ultimate structure. [on SciFinder (R)]

Published in:
Angewandte Chemie, International Edition, 45, 33, 5432-5446
CAN 145:454571
General Organic Chemistry
Institut de Chimie moleculaire et biologique,Ecole Polytechnique Federale,Lausanne,Switz.
Journal; General Review
written in English.
Other identifiers:

 Record created 2007-03-07, last modified 2018-01-27

Rate this document:

Rate this document:
(Not yet reviewed)