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A new polydentate tripodal ligand T2soxMe was synthesized to take advantage of the chelating effect of tridentate 8- hydroxyquinolinate subunits. Potentiometric and spectrophotometric titrations reveal seven pKa values of between 3.7 and 10.2. In water, the use of T2soxMe leads to thermodynamically stable and soluble LnIII complexes at physiological pH, with conditional stability constants in the range logb11=7.8..8.6. The chelates are resistant toward hydrolysis and show interesting photophysical properties, particularly in the near infrared (NIR) range. The emission lifetimes of the NdIII and YbIII complexes recorded in D2O and H2O suggest the absence of water molecules in the first coordination sphere of the metal ions. Moreover, the low energy of the triplet state allows efficient energy transfer from the ligand to the metal ions: in water at pH 7.4, the sensitization efficacy of the NIR luminescence reaches 75 and 100% for NdIII and YbIII, respectively, leading to overall quantum yields of 0.027 and 0.13%; ErIII luminescence is also detected. According to the WST-1 test, the YbIII podate at concentrations of up to 250 mm does not display sizeable cytotoxicity for Jurkat cells after 24 h of incubation. Finally, the same podate is shown to couple to human serum albumin, leading to an increase of 50% in the NIR- luminescence intensity.