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research article
Preparation and synthetic applications of 8-oxabicyclo[3.2.1]oct-6-en-3-one derivatives
2008
The development of efficient routes to multi gram quantities of chiral synthons is a key issue in total synthesis of natural products and analogues. The conformationally defined and rigid 8-oxabicyclo[3.2.1]oct-6-en-3-one template appears as an appealing starting material for the development of non iterative approaches to polyoxygenated fragments that are found in a large variety of biologically relevant natural compounds. Desymmetrization and resolution procedures, stereoselective functionalizations and double-chain elongations represent attractive strategies for such synthetic challenges.
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Type
research article
Web of Science ID
WOS:000255973000008
Publication date
2008
Published in
Volume
62
Start page
221
End page
225
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
May 20, 2008