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research article

Invalidation of the structure of genetic network dynamics: a geometric approach

Porreca, R.
•
Cinquemani, E.
•
Lygeros, J.
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2012
International Journal of Robust and Nonlinear Control

This work concerns the identification of the structure of a genetic network model from measurements of gene product concentrations and synthesis rates. In earlier work, we developed a data preprocessing algorithm that is able to reject many hypotheses on the network structure by testing certain monotonicity properties for a wide family of network models. Here we develop a geometric interpretation of the method. Then, for a relevant subclass of genetic network models, we extend our approach to the combined testing of monotonicity and convexity-like properties associated with the network structures. The theoretical aspects and practical performance of the enhanced methods are illustrated by way of numerical results.

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Type
research article
DOI
10.1002/rnc.2799
Author(s)
Porreca, R.
Cinquemani, E.
Lygeros, J.
Ferrari-Trecate, G.
Date Issued

2012

Published in
International Journal of Robust and Nonlinear Control
Volume

22

Issue

10

Start page

1140

End page

1156

Note

Special Issue on System Identification for Biological Systems

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SCI-STI-GFT  
Available on Infoscience
January 10, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/132590
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