Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Olefin Cyclopropanations via Sequential Atom Transfer Radical Addition-Dechlorination Reactions
 
research article

Olefin Cyclopropanations via Sequential Atom Transfer Radical Addition-Dechlorination Reactions

Thommes, Katrin  
•
Severin, Kay  
2010
CHIMIA

In organic synthesis, cyclopropanation reactions are often performed with Simmons Smith-type reagents or by transition metal catalyzed reactions of olefins with diazo compounds. A novel method for the synthesis of substituted cyclopropanes is described that is based on a two-step reaction sequence. Olefins are reacted with 1,1'-dichlorides in a Ru-catalyzed atom transfer radical addition (ATRA) process and the resulting 1,3-dichlorides are directly converted into cyclopropanes by reductive coupling with magnesium. This one-pot procedure is applicable to a variety of substrates and can be performed in an inter- or intramolecular fashion.

  • Details
  • Metrics
Type
research article
DOI
10.2533/chimia.2010.188
Web of Science ID

WOS:000276613600019

Author(s)
Thommes, Katrin  
Severin, Kay  
Date Issued

2010

Published in
CHIMIA
Volume

64

Start page

188

End page

190

Subjects

Carbocycles

•

Cyclopropanes

•

Magnesium

•

Radicals

•

Ruthenium

•

Kharasch Addition

•

Controlled Polymerization

•

Cyclization Reactions

•

Catalyst Precursors

•

Gaba(C) Receptors

•

Copper-Complexes

•

Reducing Agent

•

Atrc Reactions

•

Rucl(Cp-Asterisk)(Pph3)(2)

•

Reactivity

Editorial or Peer reviewed

NON-REVIEWED

Written at

EPFL

EPFL units
LCS  
Available on Infoscience
December 16, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/75600
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés