Objectives We propose an evolution of a dielectric elastomer actuator based cardiac assist device that acts as a counterpulsation system. We introduce a new pre-stretched actuator and implant the device in a graft bypass between the ascending and descending aorta to redirect all blood through the device (ascending aorta clamped). The objective was to evaluate the influence of these changes on the assistance provided to the heart. Methods The novel para-aortic device and the new implantation technique were tested in-vivo in 5 pigs. We monitored the pressure and flow in the aorta as well as the pressure-volume characteristics of the left-ventricle. Different activation timings were tested to identify the optimal device actuation. Results The proposed device helps reducing the end-diastolic pressure in the aorta by up to 13±4.0% as well as the peak systolic pressure by up to 16±3.6%. The early diastolic pressure was also increased up to 10±3.5%. With different activation we also showed that the device could increase or decrease the stroke volume. Conclusions The new setup and the novel para-aortic device presented here helped improve cardiac assistance compared to previous studies. Moreover, we revealed a new way to assist the heart by actuating the device at different starting time to modify the left ventricular stroke volume and stroke work.