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research article

Impact of population size on early adaptation in rugged fitness landscapes

Servajean, Richard  
•
Bitbol, Anne-Florence  
May 22, 2023
Philosophical Transactions Of The Royal Society B-Biological Sciences

Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases with population size, we find that the height of the first fitness peak encountered when starting from a random genotype displays various behaviours versus population size, even among small and simple rugged landscapes. We show that the accessibility of the different fitness peaks is key to determining whether this height overall increases or decreases with population size. Furthermore, there is often a finite population size that maximizes the height of the first fitness peak encountered when starting from a random genotype. This holds across various classes of model rugged landscapes with sparse peaks, and in some experimental and experimentally inspired ones. Thus, early adaptation in rugged fitness landscapes can be more efficient and predictable for relatively small population sizes than in the large-size limit.This article is part of the theme issue 'Interdisciplinary approaches to predicting evolutionary biology'.

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Type
research article
DOI
10.1098/rstb.2022.0045
Web of Science ID

WOS:000964726200009

Author(s)
Servajean, Richard  
Bitbol, Anne-Florence  
Date Issued

2023-05-22

Publisher

ROYAL SOC

Published in
Philosophical Transactions Of The Royal Society B-Biological Sciences
Volume

378

Issue

1877

Article Number

20220045

Subjects

Biology

•

Life Sciences & Biomedicine - Other Topics

•

fitness landscapes

•

epistasis

•

stochastic simulations

•

mathematical modelling

•

adaptation

•

finite-size effects

•

molecular evolution

•

predictability

•

dynamics

•

model

•

probability

•

mutations

•

selection

•

fixation

•

contacts

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPBITBOL  
Available on Infoscience
May 8, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/197368
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