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research article
Synthesis of 4-amino-1,2,3,4-tetrahydropyridine derivatives by intramolecular nucleophilic addition of tertiary enamides to in-situ generated imines
2012
The reactivity of stable tertiary enamides in nucleophilic addition reaction with various in-situ generated imines was explored. Under very mild conditions, formyl-bearing tertiary enamides reacted with both aromatic and aliphatic amines to form imine intermediates. In the absence or presence of p-toluenesulfonic acid as a catalyst, intramolecular nucleophilic addition of enamide to imine functionality proceeded effectively to produce diverse 4-amino-1,2,3,4-tetrahydropyridine derivatives in good to excellent yields.
Type
research article
Web of Science ID
WOS:000306267800012
Authors
Publication date
2012
Publisher
Published in
Volume
68
Issue
32
Start page
6492
End page
6497
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
October 1, 2012
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