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  4. Accurate Reconstruction of Right Heart Shape and Motion From Cine-MRI for Image-Driven Computational Hemodynamics
 
research article

Accurate Reconstruction of Right Heart Shape and Motion From Cine-MRI for Image-Driven Computational Hemodynamics

Renzi, Francesca
•
vergara, christian
•
Fedele, Marco
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January 1, 2025
International Journal for Numerical Methods in Biomedical Engineering

Accurate reconstruction of the right heart geometry and motion from time-resolved medical images is crucial for diagnostic enhancement and computational analysis of cardiac blood dynamics. Commonly used segmentation and/or reconstruction techniques, exclusively relying on short-axis cine-MRI, lack precision in critical regions of the right heart, such as the ventricular base and the outflow tract, due to its unique morphology and motion. Furthermore, the reconstruction procedure is time-consuming and necessitates significant manual intervention for generating computational domains. This study introduces an end-to-end hybrid reconstruction method specifically designed for computational simulations. Integrating information from various cine-MRI series (short/long-axis and 2/3/4 chambers views) with minimal user contribution, our method leverages registration- and morphing-based algorithms to accurately reconstruct crucial cardiac features and complete cardiac motion. The reconstructed data enable the creation of patient-specific computational fluid dynamics models, facilitating the analysis of the hemodynamics in healthy and clinically relevant scenarios. We assessed the accuracy of our reconstruction method against ground truth and a standard method. We also evaluated volumetric clinical parameters and compared them with the literature values. The method's adaptability was investigated by reducing the number of cine-MRI views, highlighting its robustness with varying imaging data. Numerical findings supported the reliability of the approach for simulating hemodynamics. Combining registration- and morphing-based algorithms, our method offers accurate reconstructions of the right heart chambers' morphology and motion. These reconstructions can serve as valuable tools as domain and boundary conditions for computational fluid dynamics simulations, ensuring seamless and effective analysis.

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Type
research article
DOI
10.1002/cnm.3891
Web of Science ID

WOS:001397500900001

PubMed ID

39822179

Author(s)
Renzi, Francesca

University of Verona

vergara, christian

Polytechnic University of Milan

Fedele, Marco

Polytechnic University of Milan

Giambruno, Vincenzo

University of Verona

Quarteroni, Alfio  

École Polytechnique Fédérale de Lausanne

Puppini, Giovanni

University of Verona

Luciani, Giovanni Battista

University of Verona

Date Issued

2025-01-01

Publisher

Wiley

Published in
International Journal for Numerical Methods in Biomedical Engineering
Volume

41

Issue

1

Article Number

e3891

Subjects

cardiac MRI

•

computational fluid dynamics

•

in silico investigation

•

patient-specific analysis

•

reconstruction

•

right heart

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
PH-SB  
FunderFunding(s)Grant NumberGrant URL

GNCS "Gruppo Nazionale per il Calcolo Scientifico" (National Group for Scientific Computing)

Ministry of Education, Universities and Research (MIUR)

P20223KSS2

Italian Ministry of Health within the PNC PROGETTO HUB

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Available on Infoscience
January 28, 2025
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/245600
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