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research article
Lentiviral-mediated gene transfer to model triplet repeat disorders
2004
This chapter describes the potential use of viral-mediated gene transfer in the central nervous system as a new strategy in developing animal models of neurodegenerative diseases. To illustrate the approach, procedures for the production of lentiviral vectors encoding polyQ proteins are provided, as well as methods for the determination of viral titers, in vitro infection, and basic protocols for in vivo studies in rodents.
Type
research article
Authors
Publication date
2004
Published in
Volume
277
Start page
199
End page
213
Note
Institute of Neuroscience, School of Life Sciences, Swiss Federal Institute of Technology Lausanne, Switzerland.
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
March 9, 2007
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