With the dynamics of employment growth in Luxembourg, more and more workers cross the border every day to get to their workplaces. This article proposes to study the daily lives of these cross-border workers by analysing their daily activity programmes based on a spatiotemporal approach. Different types of cross-border workers profiles are identified and characterized according to the location of their daily activities. This analysis also highlights the great complexity of their daily activity programmes. Additional qualitative analyses focusing on representations associated to their rhythms of life reveal a high intensity and many difficulties in managing all daily activities. These difficulties in reconciling the different part of their daily life have direct consequences on their quality of life and their level of integration in Luxembourg.