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  4. Reconstruction of Switching Thresholds in Piecewise-Affine Models of Genetic Regulatory Networks.
 
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Reconstruction of Switching Thresholds in Piecewise-Affine Models of Genetic Regulatory Networks.

Drulhe, S.
•
Ferrari-Trecate, G.
•
de Jong, H.
Show more
Hespanha, J.
•
Tiwari, A.
2006
Hybrid Systems: Computation and Control. HSCC 2006

Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. In this paper, we present an approach for the identification of PieceWise-Affine (PWA) models of genetic regulatory networks from experimental data, focusing on the reconstruction of switching thresholds associated with regulatory interactions. In particular, our method takes into account geometric constraints specific to models of genetic regulatory networks. We show the feasibility of our approach by the reconstruction of switching thresholds in a PWA model of the carbon starvation response in the bacterium Escherichia coli.

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Type
book part or chapter
DOI
10.1007/11730637_16
Author(s)
Drulhe, S.
Ferrari-Trecate, G.
de Jong, H.
Viari, A.
Editors
Hespanha, J.
•
Tiwari, A.
Date Issued

2006

Publisher

Springer-Verlag

Published in
Hybrid Systems: Computation and Control. HSCC 2006
Start page

184

End page

199

Series title/Series vol.

Lecture Notes in Computer Science; 3927

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SCI-STI-GFT  
Available on Infoscience
January 10, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/132649
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