Green hydrogen is gaining traction amid the global energy transition, but current production methods relying on fossil fuels are environmentally unfriendly. Water electrolysis using renewable energy is a promising alternative, yet the use of fresh water is unsustainable. Urgent development is needed to enable the use of low-grade water sources or seawater with minimal treatment.1 Proton Exchange Membrane (PEM) electrolyzers, dominant in water electrolysis, use expensive and scarce materials like platinum and iridium. The Oxygen Evolution Reaction (OER) is a bottleneck, requiring urgent developments in anode technologies as cost-effective alternatives to iridium.2 Anion Exchange Membrane (AEM) electrolysis is emerging with PGM-free materials, a sustainable shift crucial for the future of green hydrogen production. Embracing such innovations is essential for a sustainable and economically viable energy future. Hydrogen production from low-grade water sources needs a different strategy to achieve the industrially required current density of 1 A cm-2 at a low overpotential < 1.8 V, while maintaining stability and activity for hundreds of hours under the challenging electrolytes, for example containing chloride anions.3 In the EIC-funded ANEMEL project, various OER electrocatalysts have been prepared with the objective to selectively oxidize water even in the presence of chloride. In this presentation, two different families of OER electrocatalysts will be presented. First, a high entropy metal oxide containing NiFeCrMn will be studied as bifunctional electrocatalysts for both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER).4 Second, Ni-based sulfide and selenides are prepared and studied considering that a shell layer is formed which can prevent chloride anions to interact with the active sites on the surface of the catalyst.5 The synthesized electrocatalyst were characterized by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and Raman spectroscopy to confirm the material formation. Then, the sample was ex-situ characterized using linear sweep voltammetry (LSV) and chronopotentiometry in simulated alkaline seawater. Finally, the synthesized catalyst was coated on a porous substrate, and a membrane electrode assembly (MEA) was fabricated, and full cell studies such as polarization curve, hydrogen production rate, and stability of the electrocatalysts were carried out. The research findings offer further insights to demonstrate the long-term operation of hydrogen production from low-grade water sources. Acknowledgements This work was funded by the European Innovation Council Pathfinder ANEMEL (Grant agreement number 101071111). References 1. Farràs, Pau et al. Joule 2021, 1921-1923. 2. Tong, Wenming et al. Nat. Energy 2020, 5, 367-377. 3. Guo, Jiaxin et al. Nat. Energy 2023, 8, 264–272. 4. Kumar Selvam, Praveen et al. Submitted 2025. 5. Sohail Riaz, Muhammad et al. Chem. Commun. 2024, 60, 13526-13529