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2000
Synthetic routes to NEtXaa(4)-cyclosporin A derivatives as potential anti-HIV I drugs
research article
An efficient synthesis in 10 steps and overall yields up to 27% of NEtXaa(4)-cyclosporin A derivatives (Xaa = Leu, Val, Ile, Thr) starting from cyclosporin A is described. Biological activities of the new analogues show promising results for the design of cyclosporin derivatives exhibiting non-immunosuppressive and anti-HIV activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
Type
research article
Date Issued
2000
Publisher
Published in
Volume
41
Issue
37
Start page
7193
End page
7196
Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
February 9, 2006
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