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  4. Effect of Model Accuracy on the Result of Computed Current Densities in the Simulation of Transcranical Magnetic Stimulation
 
research article

Effect of Model Accuracy on the Result of Computed Current Densities in the Simulation of Transcranical Magnetic Stimulation

Golestanirad, Laleh  
•
Mattes, Michael  
•
Mosig, Juan R.  
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2010
IEEE Transactions on Magnetics

One of the most hindering limitations in the simulation of a realistic biological system is the complexity of the model which may easily lead to a very heavy computational burden. This may seriously question the possibility of optimizing system parameters and thus hinder further developments in device configuration and optimization. In this paper we study the effects of model complexity on the accuracy of the results in the computer simulation of Transcranial Magnetic Stimulation (TMS). The method has been extensively used in the last decade as a noninvasive technique to excite neurons in the brain by inducing weak electric currents in the tissue and proved to be a very promising alternative for currently invasive treatments in the cases which the increased neurogenesis is known to be beneficial such as Parkinson's and Alzheimer's diseases. A detailed 3D model of human head has been developed by combining individual patient-based brain images and the public domain Visible Human data consisting of brain white/gray matter, CSF, skull and muscles. Finite element method (low frequency Ansoft package) is used to simulate the interaction of time-varying magnetic fields with brain tissues and compute the densities of induced currents in different areas. Models with different levels of tissue separation have been developed and tested under the same condition to investigate the effects of model complexity on the distribution of fields and induced currents inside different tissues.

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Type
research article
DOI
10.1109/TMAG.2010.2082556
Web of Science ID

WOS:000284842400012

Author(s)
Golestanirad, Laleh  
Mattes, Michael  
Mosig, Juan R.  
Pollo, Claudio
Date Issued

2010

Publisher

Institute of Electrical and Electronics Engineers

Published in
IEEE Transactions on Magnetics
Volume

46

Issue

12

Start page

4046

End page

4051

Subjects

Anatomical head model

•

Finite Element Method

•

induced current density

•

patient-based model

•

Transcranial Magnetic Stimulation

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LEMA  
Available on Infoscience
March 16, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/48178
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