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research article

Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Cohen-Adad, Julien
•
Alonso-Ortiz, Eva
•
Abramovic, Mihael
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August 16, 2021
Scientific Data

In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/. The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.

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Type
research article
DOI
10.1038/s41597-021-00941-8
Web of Science ID

WOS:000686651700001

Author(s)
Cohen-Adad, Julien
Alonso-Ortiz, Eva
Abramovic, Mihael
Arneitz, Carina
Atcheson, Nicole
Barlow, Laura
Barry, Robert L.
Barth, Markus
Battiston, Marco
Buchel, Christian
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Date Issued

2021-08-16

Publisher

NATURE PORTFOLIO

Published in
Scientific Data
Volume

8

Issue

1

Start page

219

Subjects

Multidisciplinary Sciences

•

Science & Technology - Other Topics

•

of-the-art

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magnetization-transfer

•

matter

•

white

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

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Available on Infoscience
August 28, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/181049
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