research article
Synthesis and biological activity of largazole and derivatives
A modular synthesis of the marine natural product largazole and related synthetic analogs is described. Largazole was prepd. in 10% overall yield through a synthetic route with a longest linear sequence of nine steps. Activity tests showed the necessity of the thiobutenyl moiety for antiproliferative activity.
Type
research article
Author(s)
Date Issued
2008
Publisher
Published in
Volume
47
Start page
6483
End page
6485
Note
CAPLUS AN 2008:1047341(Journal)
Editorial or Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
August 17, 2011
Use this identifier to reference this record