research article
Cytotoxic profile and peculiar reactivity with biomolecules of a novel “rule-breaker” iodo-platinum(II) complex
2010
Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.
Type
research article
Web of Science ID
WOS:000284203100003
Author(s)
Messori, L.
Gabbiani, C.
Michelucci, E.
Cubo, L.
Ríos-Luci, C.
Padrón, J. M.
Navarro-Ranninger, C.
Quiroga, A. G.
Date Issued
2010
Published in
Volume
1
Start page
381
End page
385
Editorial or Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
December 20, 2010
Use this identifier to reference this record