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research article

Screening out irrelevant cell-based models of disease

Horvath, Peter
•
Aulner, Nathalie
•
Bickle, Marc
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2016
Nature Reviews Drug Discovery

The common and persistent failures to translate promising preclinical drug candidates into clinical success highlight the limited effectiveness of disease models currently used in drug discovery. An apparent reluctance to explore and adopt alternative cell-and tissue-based model systems, coupled with a detachment from clinical practice during assay validation, contributes to ineffective translational research. To help address these issues and stimulate debate, here we propose a set of principles to facilitate the definition and development of disease-relevant assays, and we discuss new opportunities for exploiting the latest advances in cell-based assay technologies in drug discovery, including induced pluripotent stem cells, three-dimensional (3D) co-culture and organ-on-a-chip systems, complemented by advances in single-cell imaging and gene editing technologies. Funding to support precompetitive, multidisciplinary collaborations to develop novel preclinical models and cell-based screening technologies could have a key role in improving their clinical relevance, and ultimately increase clinical success rates.

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Type
research article
DOI
10.1038/nrd.2016.175
Web of Science ID

WOS:000387244800016

Author(s)
Horvath, Peter
•
Aulner, Nathalie
•
Bickle, Marc
•
Davies, Anthony M.
•
Del Nery, Elaine
•
Ebner, Daniel
•
Montoya, Maria C.
•
Ostling, Paivi
•
Pietiainen, Vilja
•
Price, Leo S.
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Date Issued

2016

Publisher

Nature Publishing Group

Published in
Nature Reviews Drug Discovery
Volume

15

Issue

11

Start page

751

End page

769

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
PTCB  
Available on Infoscience
January 24, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/133719
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