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research article
A polymorphism in the HCP5 gene associated with HLA-B*5701 does not restrict HIV-1 in vitro
2010
A single-nucleotide polymorphism (rs2395029) in the HCP5 gene associated with HLA-B5701 is correlated with lower HIV-1 viral set point. The two allelic forms of coding region were ectopically expressed in TZM-bl cells for an effect on HIV-1 replication. No significant HIV-1 restriction was observed in the cells with infectivity assays throughout HIV-1 life cycle, suggesting that the association of HCP5 variant with viral control is likely due to HLA-B5701-related effect or other functional variants in the haplotype or both.
Type
research article
Authors
Yoon, Woohyun
•
Ma, Ben-Jiang
•
•
Huang, Wei
•
Xia, Shi-Mao
•
Zhang, Ruijun
•
Shianna, Kevin V.
•
Liao, Hua-Xin
•
Haynes, Barton F.
•
Goldstein, David B.
Publication date
2010
Published in
Volume
24
Issue
1
Start page
155
End page
7
Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
April 19, 2011
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