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  4. Orientation invariant and non-parametric Axon Diameter Distribution mapping using PGSE and regularized discrete linear modeling
 
conference paper

Orientation invariant and non-parametric Axon Diameter Distribution mapping using PGSE and regularized discrete linear modeling

Romascano, David Paul Roger  
•
Barakovic, Muhamed  
•
Auría Rasclosa, Anna  
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2017
Proceedings of the 24th annual meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
25th annual meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)

Axon Diameter Distributions (ADDs) change during brain development and are altered in several brain pathologies. Mapping ADDs non-invasively using dMRI could provide a useful biomarker, but existing methods are either parametric, orientation dependent, surmmarize the whole ADD as a single measure or use non-standard protocols. We propose to estimate the ADD from an orientation-invariant PGSE protocol optimized for axon diameter sensitivity, using a discrete linear model with smoothness and sparsity regularization. To our knowledge, we are the first to report orientationally invarant ADD estimates from dMRI data.

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Type
conference paper
Author(s)
Romascano, David Paul Roger  
Barakovic, Muhamed  
Auría Rasclosa, Anna  
Dyrby, Tim B.
Thiran, Jean-Philippe  
Daducci, Alessandro  
Date Issued

2017

Published in
Proceedings of the 24th annual meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)
Subjects

non-parametric ADD mapping

•

microstructure

•

diffusion MRI

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTS5  
Event nameEvent placeEvent date
25th annual meeting of the International Society for Magnetic Resonance in Medicine (ISMRM)

Honolulu, HI, USA

April 22-27, 2017

Available on Infoscience
January 6, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/132496
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