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research article

High-density electrode array for imaging in vitro electrophysical activity

Berdondini, L.
•
van der Wal, P. D.  
•
Guenat, O.
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2005
Biosensors & Bioelectronics

The development of a high-density active microelectrode array for in vitro electrophysiology is reported. Based on the Active Pixel Sensor (APS) concept, the array integrates 4096 gold microelectrodes (electrode separation 20 μm) on a surface of 2.5 mm x 2.5 mm as well as a high-speed random addressing logic allowing the sequential selection of the measuring pixels. Following the electrical characterization in a phosphate solution, the functional evaluation has been carried out by recording the spontaneous electrical activity of neonatal rat cardiomyocytes. Signals with amplitudes from 130 μV p-p to 300 μVp-p could be recorded from different pixels. The results demonstrate the suitability of the APS concept for developing a new generation of high-resolution extracellular recording devices for in vitro electrophysiology. © 2004 Elsevier B.V. All rights reserved.

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Type
research article
DOI
10.1016/j.bios.2004.08.011
Author(s)
Berdondini, L.
•
van der Wal, P. D.  
•
Guenat, O.
•
de Rooij, N. F.  
•
Koudelka-Hep, M.
•
Seitz, P.
•
Kaufmann, R.
•
Metzler, P.
•
Blanc, N.
•
Rohr, S.
Date Issued

2005

Published in
Biosensors & Bioelectronics
Volume

21

Start page

167

End page

174

Note

339

Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SAMLAB  
Available on Infoscience
May 12, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/39014
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