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review article
Lrig1: a new master regulator of epithelial stem cells
2012
The intestine represents the most vigorously renewing, adult epithelial tissue that makes maintenance of its homeostasis a delicate balance between proliferation, cell cycle arrest, migration, differentiation, and cell death. These processes are precisely controlled by a network of developmental signalling cascades, which include Wnt, Notch, BMP/TGF beta, and Hedgehog pathways. A new, elegant study by Wong et al (2012) now adds Lrig1 as a key player in the control of intestinal homeostasis. As for epidermal stem cells, Lrig1 limits the size of the intestinal progenitor compartment by dampening EGF/ErbB-triggered stem cell expansion.
Type
review article
Web of Science ID
WOS:000303596900002
Authors
Publication date
2012
Published in
Volume
31
Issue
2
Start page
2064
End page
2066
Peer reviewed
NON-REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
April 2, 2012
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