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research article

Transverse Detection of DNA Using a MoS2 Nanopore

Graf, Michael  
•
Lihter, Martina  
•
Altus, Damir
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December 1, 2019
Nano Letters

Classical nanopore sensing relies on the measurement of the ion current passing through a nanopore. Whenever a molecule electrophoretically translocates through the narrow constriction, it modulates the ion current. Although this approach allows one to measure single molecules, the access resistance limits the spatial resolution. This physical limitation could potentially be overcome by an alternative sensing scheme taking advantage of the current across the membrane material itself. Such an electronic readout would also allow better temporal resolution than the ionic current. In this work, we present the fabrication of an electrically contacted molybdenum disulfide (MoS2) nanoribbon integrated with a nanopore. DNA molecules are sensed by correlated signals from the ionic current through the nanopore and the transverse current through the nanoribbon. The resulting signal suggests a field-effect sensing scheme where the charge of the molecule is directly sensed by the nanoribbon. We discuss different sensing schemes such as local potential sensing and direct charge sensing. Furthermore, we show that the fabrication of freestanding MoS2 ribbons with metal contacts is reliable and discuss the challenges that arise in the fabrication and usage of these devices.

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Type
research article
DOI
10.1021/acs.nanolett.9b04180
Web of Science ID

WOS:000502687500092

Author(s)
Graf, Michael  
Lihter, Martina  
Altus, Damir
Marion, Sanjin  
Radenovic, Aleksandra  
Date Issued

2019-12-01

Published in
Nano Letters
Volume

19

Issue

12

Start page

9075

End page

9083

Subjects

Chemistry, Multidisciplinary

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Chemistry, Physical

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Nanoscience & Nanotechnology

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Materials Science, Multidisciplinary

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Physics, Applied

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Physics, Condensed Matter

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Chemistry

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Science & Technology - Other Topics

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Materials Science

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Physics

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field-effect transistor

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dna detection

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nanopore

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nanoribbon

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molybdenum disulfide

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mos2

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graphene nanoribbon

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current signals

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single

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translocation

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nucleotides

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noise

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conductance

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proteins

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energy

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LBEN  
Available on Infoscience
January 2, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/164287
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