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research article

Neural Basis of Internal Attention in Adults with Pure and Comorbid ADHD

Rafi, Halima
•
Murray, Ryan
•
Delavari, Farnaz  
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January 12, 2023
Journal Of Attention Disorders

Objective: To examine whether putatively atypical neuronal activity during internal attention in ADHD yields insights into processes underlying emotion dysregulation. Methods: We used a word processing paradigm to assess neural activations in adults with ADHD (N = 46) compared to controls (N = 43). We measured effects of valence, applied partial-least squares correlation analysis to assess multivariate brainbehavior relationships and ran subgroup analyses to isolate results driven by pure ADHD (N = 18). Results: During internal attention, ADHD, compared to controls, have (1) increased activation in the right angular gyrus (rAG), which appears driven by pure, not comorbid, ADHD and (2) diminished activation in the insula and fronto-striatal circuitry. Diminished activations were driven by negatively-valenced internal attention and negatively correlated with increased affective lability within the ADHD group. Conclusion: Internal attention in ADHD is associated with increased rAG activation, possibly reflecting difficulty converging external and internal information, and diminished activation within emotion regulation circuitry.

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Type
research article
DOI
10.1177/10870547221147546
Web of Science ID

WOS:000913072900001

Author(s)
Rafi, Halima
•
Murray, Ryan
•
Delavari, Farnaz  
•
Perroud, Nader
•
Vuilleumier, Patrik
•
Debbane, Martin
•
Piguet, Camille
Date Issued

2023-01-12

Published in
Journal Of Attention Disorders
Subjects

Psychology, Developmental

•

Psychiatry

•

Psychology

•

Psychiatry

•

adult adhd

•

fmri

•

comorbidity

•

deficit hyperactivity disorder

•

temporal receptive windows

•

deficit/hyperactivity disorder

•

emotional dysregulation

•

anterior insula

•

brain

•

networks

•

children

•

interoception

•

activation

Peer reviewed

REVIEWED

Written at

EPFL

Available on Infoscience
February 13, 2023
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/194812
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