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research article
Native Architecture of the Centriole Proximal Region Reveals Features Underlying Its 9-Fold Radial Symmetry
2013
Centrioles are cylindrical microtubule-based structures whose assembly is critical for the formation of cilia, flagella, and centrosomes. The centriole proximal region harbors a cartwheel that dictates the 9-fold symmetry of centrioles. Although the cartwheel architecture has been recently analyzed, how it connects to the peripheral microtubules is not understood. More generally, a high-resolution view of the proximal region of the centriole is lacking, thus limiting understanding of the underlying assembly mechanisms.
Type
research article
Web of Science ID
WOS:000330098200030
Authors
•
Hachet, Virginie
•
Majubu, Norbert
•
Neves, Aitana
•
Demurtas, Davide
•
Olieric, Natacha
•
Fluckiger, Isabelle
•
Yamada, Akinori
•
Kihara, Kumiko
•
Nishida, Yuichiro
Publication date
2013
Published in
Volume
23
Issue
17
Start page
1620
End page
1628
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
August 13, 2013
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