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research article

Post-translational glycosylation diminishes α-synuclein pathology formation

Pratt, Matthew
•
Lashuel, Hilal  
February 14, 2024
Nature Chemical Biology

O-linked N-acetylglucosamine (O-GlcNAc) is an endogenous form of glycosylation that alters the structure of alpha-synuclein amyloid fibrils and attenuates their pathogenetic properties. The modified fibrils have a significantly reduced ability to seed the aggregation of endogenous alpha-synuclein in cultured neurons and in mice brains in vivo, which results in reduced pathology.

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Type
research article
DOI
10.1038/s41589-024-01553-0
Web of Science ID

WOS:001162200100001

Author(s)
Pratt, Matthew
•
Lashuel, Hilal  
Date Issued

2024-02-14

Publisher

Nature Portfolio

Published in
Nature Chemical Biology
Subjects

Life Sciences & Biomedicine

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LMNN  
Available on Infoscience
March 18, 2024
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/206392
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