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research article
Isolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum
INH-resistant mutants of Mycobacterium aurum and M. smegmatis were isolated and characterized in an attempt to provide fresh insight into the activity of isoniazid (INH), a key antibiotic in the treatment of tuberculosis. In both cases, high levels of resistance were accompanied by slower growth rate, by loss of peroxidase and reduced catalase activities, although mycolic acid production was unaffected. A gene homologous to the katG gene of M. tuberculosis, encoding peroxidase-catalase, was detected in wild-type and INH-resistant strains and it appears that INH resistance may stem from the loss of its product.
Type
research article
PubMed ID
1488556
Authors
Publication date
1992
Published in
Volume
143
Issue
7
Start page
721
End page
30
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
September 7, 2010
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