The usage of industrial by-products and natural resources has already been acknowledged as a viable option for lowering the CO2 emissions in cement production. The utilization of locally available materials as supplementary cementitious material (SCM) presents an opportunity to produce more sustainable cements that could satisfy the growing concrete demand. However, the composition of these materials is origin related and can differ from region to region. For that reason, this study correlates the physical and chemical properties of local materials with their mechanical performance when used as SCM. Twelve different samples were collected: three slags, two fly ashes, one silica fume, and six clays. The R3 reactivity test was performed together with compressive strength tests on mortars after 2, 7 and 28 days. Finally, the paper presents the most suitablematerials prioritising the results according to the obtained data. With the screening approach, this research brings attention to the key parameters that are vital for preliminary SCM identification.