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  4. A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior
 
research article

A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior

Graf, Juergen
•
Zhang, Chuanqiang  
•
Marguet, Stephan Lawrence
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April 6, 2021
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)

NKCC1 is the primary transporter mediating chloride uptake in immature principal neurons, but its role in the development of in vivo network dynamics and cognitive abilities remains unknown. Here, we address the function of NKCC1 in developing mice using electrophysiological, optical, and behavioral approaches. We report that NKCC1 deletion from telencephalic glutamatergic neurons decreases in vitro excitatory actions of gamma-aminobutyric acid (GABA) and impairs neuronal synchrony in neonatal hippocampal brain slices. In vivo, it has a minor impact on correlated spontaneous activity in the hippocampus and does not affect network activity in the intact visual cortex. Moreover, long-term effects of the developmental NKCC1 deletion on synaptic maturation, network dynamics, and behavioral performance are subtle. Our data reveal a neural network function of NKCC1 in hippocampal glutamatergic neurons in vivo, but challenge the hypothesis that NKCC1 is essential for major aspects of hippocampal development.

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Type
research article
DOI
10.1073/pnas.2014784118
Web of Science ID

WOS:000637398300021

Author(s)
Graf, Juergen
•
Zhang, Chuanqiang  
•
Marguet, Stephan Lawrence
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Herrmann, Tanja
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Flossmann, Tom
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Hinsch, Robin
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Rahmati, Vahid
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Guenther, Madlen
•
Frahm, Christiane
•
Urbach, Anja
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Date Issued

2021-04-06

Publisher

National Academy of Sciences

Published in
Proceedings Of The National Academy Of Sciences Of The United States Of America (PNAS)
Volume

118

Issue

14

Article Number

e2014784118

Subjects

Multidisciplinary Sciences

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Science & Technology - Other Topics

•

gaba

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nkcc1

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hippocampus

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development

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in vivo

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LSENS  
Available on Infoscience
May 22, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/178322
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