We present an operational estimation procedure for the estimation of route choice multivariate extreme value (MEV) models based on sampling of alternatives. The procedure builds on the state-of-the-art literature, and in particular on recent methodological developments proposed by Flötteröd and Bierlaire (2013) and Guevara and Ben-Akiva (2013b). Case studies on both synthetic data and a real network demonstrate that the new method is valid and practical.