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review article

Macrophage regulation of tumor responses to anticancer therapies

De Palma, Michele  
•
Lewis, Claire E.
2013
Cancer cell

Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like angiogenesis, immunosuppression, invasion, and metastasis. Increasing studies have also shown that TAMs can either enhance or antagonize the antitumor efficacy of cytotoxic chemotherapy, cancer-cell targeting antibodies, and immunotherapeutic agents--depending on the type of treatment and tumor model. TAMs also drive reparative mechanisms in tumors after radiotherapy or treatment with vascular-targeting agents. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target TAMs to increase the efficacy of such therapies.

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Type
review article
DOI
10.1016/j.ccr.2013.02.013
Author(s)
De Palma, Michele  
•
Lewis, Claire E.
Date Issued

2013

Published in
Cancer cell
Volume

23

Issue

3

Start page

277

End page

86

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPDEPALMA  
Available on Infoscience
September 5, 2013
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/94468
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