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  4. Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept
 
research article

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

Mimna, Richard
•
Camus, Marie-Stephanie  
•
Schmid, Adrian  
Show more
2007
Angewandte Chemie International Edition

Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and clearance.

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Type
research article
DOI
10.1002/anie.200603681
Web of Science ID

WOS:000245614600031

Author(s)
Mimna, Richard
•
Camus, Marie-Stephanie  
•
Schmid, Adrian  
•
Tuchscherer, Gabriele  
•
Lashuel, Hilal A.  
•
Mutter, Manfred  
Date Issued

2007

Publisher

Wiley-VCH Verlag GmbH

Published in
Angewandte Chemie International Edition
Volume

46

Issue

15

Start page

2681

End page

2684

Subjects

Conformational transition

•

Self-assembly

•

alpha-Helix

•

beta-Sheet (disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation)

•

Amyloid Role: BSU (Biological study

•

unclassified)

•

PRP (Properties)

•

BIOL (Biological study) (disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation)

•

Conformation

•

Secondary structure (protein

•

disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation)

•

amyloid peptide beta sheet alpha helix secondary structure

Note

Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and clearance.

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

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LMNN  
LCBP  
Available on Infoscience
July 31, 2007
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/9988
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