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research article

The consequences of not accounting for background selection in demographic inference

Ewing, Gregory B.
•
Jensen, Jeffrey D.  
2016
Molecular Ecology

Recently, there has been increased awareness of the role of background selection (BGS) in both data analysis and modelling advances. However, BGS is still difficult to take into account because of tractability issues with simulations and difficulty with nonequilibrium demographic models. Often, simple rescaling adjustments of effective population size are used. However, there has been neither a proper characterization of how BGS could bias or shift inference when not properly taken into account, nor a thorough analysis of whether rescaling is a sufficient solution. Here, we carry out extensive simulations with BGS to determine biases and behaviour of demographic inference using an approximate Bayesian approach. We find that results can be positively misleading with significant bias, and describe the parameter space in which BGS models replicate observed neutral nonequilibrium expectations.

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Type
research article
DOI
10.1111/mec.13390
Web of Science ID

WOS:000367908800010

Author(s)
Ewing, Gregory B.
Jensen, Jeffrey D.  
Date Issued

2016

Publisher

Wiley-Blackwell

Published in
Molecular Ecology
Volume

25

Issue

1

Start page

135

End page

141

Subjects

evolutionary theory

•

natural selection and contemporary evolution

•

population dynamics

•

population genetics-theoretical

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPJENSEN  
Available on Infoscience
February 16, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/123783
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