It is well-known that the morphology of urban areas modifies the variations of climate variables at microscale; known as microclimate conditions. The complexity of urban morphology can lead to undesired wind conditions or excessive air temperature; particularly in extreme weather conditions. This study attempts to quantify the impacts of urban morphology on the evolution of wind speed and air temperature at the urban canopy layer using Computational Fluid Dynamic (CFD) simulations. In this regard, three urban neighbourhoods are generated based on a novel urban morphology parameterization method and assessed in two extreme low and high wind conditions. Results showed that wind speed (up to 75%) and air temperature (up to 28%) at the microscale can get amplified or dampened in extreme conditions. A negative correlation was observed between wind speed and air temperature variations indicating a great potential to reduce outdoor air temperature through heat removal in urban canyons. The findings of the study are categorized based on the morphological parameters to present a series of design-based strategies for the newly-built urban neighbourhoods.