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review article

Pore-forming toxins and cellular non-immune defenses (CNIDs)

Aroian, Raffi
•
van der Goot, F. G.  
2007
Current opinion in microbiology

Pore-forming toxins (PFTs) are the most common class of bacterial protein toxin and are important for bacterial pathogenesis. Recent studies have shown that the previous model stating that epithelial cells lyse in response to these toxins and have no defenses against these pores is oversimplified. Rather, it appears that cells have sophisticated mechanisms and signal-transduction pathways with which to respond to such an attack. There is a growing body of knowledge about how cells respond to and protect themselves against PFTs; this protection against PFTs is likely to be important in host survival to attack by bacterial pathogens, but does not neatly fit into current concepts of adaptive or innate immunity. Therefore, it is proposed that the terminology cellular non-immune defenses (CNIDs) be used to describe defenses that are employed by non-immune cells to protect against bacterial attack.

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Type
review article
DOI
10.1016/j.mib.2006.12.008
Web of Science ID

WOS:000244809900010

Author(s)
Aroian, Raffi
•
van der Goot, F. G.  
Date Issued

2007

Publisher

Elsevier

Published in
Current opinion in microbiology
Volume

10

Issue

1

Start page

57

End page

61

Peer reviewed

NON-REVIEWED

Written at

EPFL

EPFL units
VDG  
Available on Infoscience
July 29, 2010
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/51911
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