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  4. In-flow electrochemical detection of chemicals in droplets with pyrolysed photoresist electrodes: application as a module for quantification of microsampled dopamine
 
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research article

In-flow electrochemical detection of chemicals in droplets with pyrolysed photoresist electrodes: application as a module for quantification of microsampled dopamine

Leroy, Albert  
•
Teixidor, Joan  
•
Bertsch, Arnaud  
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June 30, 2021
Lab On A Chip

The electrochemical quantification of analytes in droplets of PBS separated by a fluorinated phase was investigated. PDMS-fused silica chips with pyrolysed photoresist electrodes were prepared using a simple fabrication technique and used to analyze droplets in flow. Potentiostatic chronoamperometry provided current readouts consistent with mass transport and the concentration inside the droplets. This paper highlights measurements of dopamine in droplets in T-junction microfluidic chips at unprecedently low concentrations, with a limit of detection of 207 nM and a linear range of 0.21-20 mu M, giving results similar to continuous flow electrochemistry and allowing the analysis in the striatal extracellular range (<1 mu M). The system was applied to the quick and reliable on-line detection of dopamine concentration steps in droplets collected with a microsampling probe in vitro, demonstrating the usefulness of the electrochemical device as a quantification module for microsampled chemicals in droplets.

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Type
research article
DOI
10.1039/d1lc00116g
Web of Science ID

WOS:000671840600001

Author(s)
Leroy, Albert  
•
Teixidor, Joan  
•
Bertsch, Arnaud  
•
Renaud, Philippe  
Date Issued

2021-06-30

Publisher

ROYAL SOC CHEMISTRY

Published in
Lab On A Chip
Volume

21

Issue

17

Start page

3328

End page

3337

Subjects

Biochemical Research Methods

•

Chemistry, Multidisciplinary

•

Chemistry, Analytical

•

Nanoscience & Nanotechnology

•

Instruments & Instrumentation

•

Biochemistry & Molecular Biology

•

Chemistry

•

Science & Technology - Other Topics

•

carbon-paste electrodes

•

microfluidic chip

•

temporal resolution

•

segmented flow

•

microelectrodes

•

microdialysis

•

voltammetry

•

fabrication

•

collection

•

serotonin

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LMIS4  
Available on Infoscience
July 31, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/180248
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