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review article

The not so identical twins: (dis)similarities between reactive electrophile and oxidant sensing and signaling

Long, Marcus J. C.
•
Huang, Kuan-Ting  
•
Aye, Yimon  
August 20, 2021
Chemical Society Reviews

In this tutorial review, we compare and contrast the chemical mechanisms of electrophile/oxidant sensing, and the molecular mechanisms of signal propagation. We critically analyze biological systems in which these different pathways are believed to be manifest and what the data really mean. Finally, we discuss applications of this knowledge to disease treatment and drug development.

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Type
review article
DOI
10.1039/d1cs00467k
Web of Science ID

WOS:000686711100001

Author(s)
Long, Marcus J. C.
•
Huang, Kuan-Ting  
•
Aye, Yimon  
Date Issued

2021-08-20

Publisher

ROYAL SOC CHEMISTRY

Published in
Chemical Society Reviews
Volume

50

Issue

22

Start page

12269

End page

12291

Subjects

Chemistry, Multidisciplinary

•

Chemistry

•

hydrogen-peroxide

•

amino-acids

•

methionine oxidation

•

kinetic-analysis

•

protein

•

glutathione

•

proteasome

•

cysteine

•

thiols

•

probe

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LEAGO  
Available on Infoscience
September 11, 2021
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/181258
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