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research article
Overexpression of a mutant form of TGFBI/BIGH3 induces retinal degeneration in transgenic mice
2008
Purpose: Despite ubiquitous expression of the keratoepithelin (KE) protein encoded by the transforming growth factor beta induced/beta induced gene human clone 3 (TGFBI/BIGH3) gene, corneal dystrophies are restricted to the cornea, and no other tissues are affected. We investigated the role of TGFBI/BIGH3 in Groenouw corneal dystrophies by generating transgenic mice overexpressing TGFBI/BIGH3 containing the R555W mutation.
Type
research article
Web of Science ID
WOS:000257890600002
Authors
Bustamante, Mauro
•
Tasinato, Andrea
•
Maurer, Fabienne
•
Elkochairi, Ilhem
•
Lepore, Mario G.
•
Arsenijevic, Yvan
•
Pedrazzini, Thierry
•
Munier, Francis L.
•
Schorderet, Daniel F.
Publication date
2008
Published in
Volume
14
Start page
1129
End page
1137
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 30, 2010
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