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research article
Synthesis and chemical transformations of diazolyl alpha,alpha-difluoroacetates
January 1, 2020
Optimized protocols for the synthesis of diazolyl alpha,alpha-difluoroacetates via deoxofluorination of the corresponding glyoxylates with Morph-DAST are described. The method allowed the preparation of the title fluoridated building blocks in 73-96 % yield on up to 15 g scale. Utility of the hetaryl alpha,alpha-difluoroacetates was demonstrated by the synthesis of advanced building blocks for medicinal chemistry, i.e. carboxylic acids, amides, nitriles, and alcohols.
Type
research article
Web of Science ID
WOS:000509631900009
Authors
Geraschenko, Oleksandr V.
•
Solomin, Vitalii V.
•
Vashchenko, Bohdan V.
•
•
Tolmachev, Andrey A.
•
Grygorenko, Oleksandr O.
Publication date
2020-01-01
Publisher
Published in
Volume
229
Article Number
109407
Peer reviewed
REVIEWED
Written at
EPFL
EPFL units
Available on Infoscience
March 3, 2020
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