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review article

Targeting Bacterial Central Metabolism for Drug Development

Murima, Paul  
•
Mckinney, John D.  
•
Pethe, Kevin
2014
Chemistry & Biology

Current antibiotics, derived mainly from natural sources, inhibit a narrow spectrum of cellular processes, namely DNA replication, protein synthesis, and cell wall biosynthesis. With the worldwide explosion of drug resistance, there is renewed interest in the investigation of alternate essential cellular processes, including bacterial central metabolic pathways, as a drug target space for the next generation of antibiotics. However, the validation of targets in central metabolism is more complex, as essentiality of such targets can be conditional and/or contextual. Bearing in mind our enhanced understanding of prokaryotic central metabolism, a key question arises: can central metabolism be bacteria's Achilles' heel and a therapeutic target for the development of new classes of antibiotics? In this review, we draw lessons from oncology and attempt to address some of the open questions related to feasibility of targeting bacterial central metabolism as a strategy for developing new antibacterial drugs.

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Type
review article
DOI
10.1016/j.chembiol.2014.08.020
Web of Science ID

WOS:000345506900003

Author(s)
Murima, Paul  
•
Mckinney, John D.  
•
Pethe, Kevin
Date Issued

2014

Publisher

Elsevier

Published in
Chemistry & Biology
Volume

21

Issue

11

Start page

1423

End page

1432

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPKIN  
Available on Infoscience
December 30, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/109668
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