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  4. Synthesis, characterization and anticancer studies of mixed ligand dithiocarbamate palladium(II) complexes
 
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research article

Synthesis, characterization and anticancer studies of mixed ligand dithiocarbamate palladium(II) complexes

Khan, Hizbullah
•
Badshah, Amin
•
Murtaz, Ghulam
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2011
European Journal Of Medicinal Chemistry

Six mixed ligand dithiocarbamate Pd(II) complexes (1-6) of general formula [(DT)Pd(PR3)Cl], where DT = dimethyldithiocarbamate (1, 5), diethyldithiocarbamate (2, 3), dicyclohexyldithiocarbamate (4), bis(2-methoxyethyl)dithiocarbamate (6); PR3 = benzyldiphenylphosphine (1), dipheny1-2-methoxy-phenylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-m-tolylphosphine (4), tricyclohexylphosphine (5), diphenyl-2-pyridylphosphine (6) have been synthesized and characterised using Elemental analysis, FT-IR, Raman and multinuclear magnetic resonance (NMR) spectroscopy. Compounds 1 and 2 were also characterized by single crystal X-ray diffraction technique (XRD). The XRD study reveals that the Pd(II) moiety has a pseudo square-planar geometry, in which two positions are occupied by the dithiocarbamate ligand in a bidentate fashion, while at the remaining two positions organophosphine and chloride are present. The anticancer activity of the synthesized metallodrugs was checked against DU145 human prostate carcinoma (HTB-81) cells, the IC50 values indicate that the compounds are highly active against these cells. These Pd(II) complexes also show moderate antibacterial activity against gram positive and gram negative bacteria. (C) 2011 Elsevier Masson SAS. All rights reserved.

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Type
research article
DOI
10.1016/j.ejmech.2011.06.007
Web of Science ID

WOS:000295237400056

Author(s)
Khan, Hizbullah
•
Badshah, Amin
•
Murtaz, Ghulam
•
Said, Muhammad
•
Rehman, Zia-ur-
•
Neuhausen, Christine
•
Todorova, Margarita
•
Jean-Claude, Bertrand J.
•
Butler, Ian S.
Date Issued

2011

Published in
European Journal Of Medicinal Chemistry
Volume

46

Start page

4071

End page

4077

Subjects

Palladium(II)

•

Dithiocarbamate

•

Du145

•

Crystal structure

•

Mixed ligand

•

Alpha-Amino-Acids

•

In-Vitro

•

Nmr-Spectroscopy

•

Cytotoxicity

•

Dna

•

Drugs

•

Derivatives

•

Cisplatin

•

Pd(Ii)

•

Pt(Ii)

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCR  
Available on Infoscience
December 16, 2011
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/73483
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