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  4. Probing myelin content of the human brain with MRI: A review
 
review article

Probing myelin content of the human brain with MRI: A review

Piredda, Gian Franco
•
Hilbert, Tom  
•
Thiran, Jean-Philippe  
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2021
Magnetic Resonance In Medicine

Rapid and efficient transmission of electric signals among neurons of vertebrates is ensured by myelin-insulating sheaths surrounding axons. Human cognition, sensation, and motor functions rely on the integrity of these layers, and demyelinating diseases often entail serious cognitive and physical impairments. Magnetic resonance imaging radically transformed the way these disorders are monitored, offering an irreplaceable tool to noninvasively examine the brain structure. Several advanced techniques based on MRI have been developed to provide myelin-specific contrasts and a quantitative estimation of myelin density in vivo. Here, the vast offer of acquisition strategies developed to date for this task is reviewed. Advantages and pitfalls of the different approaches are compared and discussed.

  • Details
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Type
review article
DOI
10.1002/mrm.28509
Web of Science ID

WOS:000569463300001

Author(s)
Piredda, Gian Franco
•
Hilbert, Tom  
•
Thiran, Jean-Philippe  
•
Kober, Tobias  
Date Issued

2021

Publisher

WILEY

Published in
Magnetic Resonance In Medicine
Volume

95

Issue

2

Start page

627

End page

652

Subjects

Radiology, Nuclear Medicine & Medical Imaging

•

human brain

•

macromolecular content

•

mri

•

myelin

•

myelin water imaging

•

appearing white-matter

•

inhomogeneously broadened lines

•

magnetization-transfer ratio

•

ute pulse sequences

•

high-field mri

•

in-vivo

•

multiple-sclerosis

•

water fraction

•

gradient-echo

•

quantitative interpretation

Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTS5  
GR-SCI-IEL  
Available on Infoscience
October 1, 2020
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/172061
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