A finite-element approach based on the first-order FE2 homogenisation technique is formulated to analyse the alkali-silica reaction-induced damage in concrete structures, by linking the concrete degradation at the macro-scale to the reaction extent at the meso-scale. At the meso-scale level, concrete is considered as a heterogeneous material consisting of aggregates embedded in a mortar matrix. The mechanical effects of the Alkali-Silica Reaction (ASR) are modelled through the application of temperature-dependent eigenstrains in several localised spots inside the aggregates, and the mechanical degradation of concrete is modelled using continuous damage model, which is capable of reproducing the complex ASR crack networks. Then, the effective stiffness tensor and the effective stress tensor for each macroscopic finite element are computed by homogenising the mechanical response of the corresponding representative volume element (RVE). Convergence between macro- and meso-scales is achieved via an iterative procedure. A 2D model of an ASR laboratory specimen is analysed as a proof of concept. The model is able to account for the loading applied at the macro-scale and the ASR-product expansion at the meso-scale. The results demonstrate that the macroscopic stress state influences the orientation of damage inside the underlying RVEs. The effective stiffness becomes anisotropic in cases where damage is aligned inside the RVE. (C) 2020 The Authors. Published by Elsevier Ltd.